HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 54539209, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzonitrile, 4-chloro-3-nitro- | HCID 13655 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(Pyrimidin-4-yl)aniline | HCID 12456171 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 54539209 | HCID 54539209 | 96.6% |
Reaction Steps
To a mixture of 4-chloro-3-nitrobenzonitril (5.5 g, 30 mmol) and (58) (5.1 g, 30 mmol) in THF (120 ml) was added sodium hydride (2.3 g, 50% suspension in mineral oil). After stirring at room temperature for 2 days, the mixture was poured into water and extracted with CH2Cl2. The extract was concentrated under reduced pressure and the residue was triturated with diethylether to yield crystalline (59) (9.2 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05922725 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-d0b093f34e9d4a2097649974f295b5e1 |
| Source note | uspto-grants-1999_07 |