O-Methylhydroxylamine hydrochloride → HCID 87417166, compound

HRID 581924Notes

Reaction equation

HRID 581924 reaction equation
[CH:1]([C:3]1[CH:23]=[CH:22][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]4[N:21]=[CH:20][CH:19]=[CH:18][N:17]=4)[CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1)=O.[NH2:24][O:25][CH3:26].Cl>>[CH3:26][O:25][N:24]=[CH:1][C:3]1[CH:23]=[CH:22][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]4[N:17]=[CH:18][CH:19]=[CH:20][N:21]=4)[CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 53950270HCID 53950270, compound

Product 1

HCID 87417166HCID 87417166, compoundYield 83.3%

Procedure

was synthesized as described in Example 22 but using (68) (210 mg, 0.70 mmol) instead of (55) and NH2OMe.HCl (300 mg, 3.6 mmol) instead of NH2OH.HCl. The reaction gave (69) (192 mg, 83%). Mp. 158-159° C.

Workup

  1. customwas synthesized

Sources & evidence

ORD record
ord-6bf1885cdd3745fc8ef3cad3a0a1c077
Source dataset
uspto-grants-1999_07
Patent number
US05922725

Reaction notes

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