Sodium Hydroxide → 5-Trifluoromethyl-6-methoxybenzo[b]thiophene-3-carboxylic acid

HRID 581984Notes

Reaction equation

[F:1][C:2]([F:20])([F:19])[C:3]1[C:16]([O:17][CH3:18])=[CH:15][C:6]2[S:7][CH:8]=[C:9]([C:10]([O:12]CC)=[O:11])[C:5]=2[CH:4]=1.[OH-].[Na+]>>[F:20][C:2]([F:1])([F:19])[C:3]1[C:16]([O:17][CH3:18])=[CH:15][C:6]2[S:7][CH:8]=[C:9]([C:10]([OH:12])=[O:11])[C:5]=2[CH:4]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 53925736Ethyl 5-trifluoromethyl-6-methoxybenzo[b]thiophene-3-carboxylate

Product 1

HCID 540774745-Trifluoromethyl-6-methoxybenzo[b]thiophene-3-carboxylic acidYield 92%

Procedure

Ethyl 5-trifluoromethyl-6-methoxybenzo[b]thiophene-3-carboxylate (D6) (0.5 g, 2 mmoles) was treated with sodium hydroxide as in the method of description 5 to give the title compound (D7) (0.42 g, 92%)

Sources & evidence

ORD record: ord-2b20f271724b47dabebac6679b357d37
Source dataset: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05922733

Reaction notes

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