HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (5-Chloro-6-quinolinyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (+/-)-2-Methoxy-alpha-[3-(trifluoromethyl)phenyl]-6-quinoline methanol | HCID 54187627 | — |
| Product | (5-Chloro-6-quinolinyl)methanol | HCID 45588508 | — |
Reaction Steps
A mixture of intermediate 28 (1 g) and HCl (25 ml; 3 N) was stirred and refluxed for 2 hours. The solution was basified with NaOH and extracted with CH2Cl2. The organic layer was separated, washed with brine, dried over MgSO4, filtered and the solvent was evaporated, yielding 1.8 g of (±)-6-[hydroxy[3-(trifluoromethyl)phenyl]methyl]-2(1H-quinolinone (intermediate 29).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05922734 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-b1e413b95cdf4556be0200fb3f8e4c58 |
| Source note | uspto-grants-1999_07 |