反应详情

A mixture of intermediate 28 (1 g) and HCl (25 ml; 3 N) was stirred and refluxed for 2 hours. The solution was basified with NaOH and extracted with CH2Cl2. The organic layer was separated, washed with brine, dried over MgSO4, filtered and the solvent was evaporated, yielding 1.8 g of (±)-6-[hydroxy[3-(trifluoromethyl)phenyl]methyl]-2(1H-quinolinone (intermediate 29).

1. temperaturerefluxed for 2 hours
2. extractionextracted with CH2Cl2
3. customThe organic layer was separated
4. washwashed with brine
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customthe solvent was evaporated