1-Piperidinecarboxylic acid, 4-(1H-benzimidazol-2-ylamino)-, ethyl ester → (1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine

HRID 582089Notes

Reaction equation

HRID 582089 reaction equation
[F:1][C:2]([F:13])([F:12])[CH2:3][O:4][CH2:5][CH2:6]OS(C)(=O)=O.[NH:14]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:16]=[C:15]1[NH:23][CH:24]1[CH2:29][CH2:28][N:27](C(OCC)=O)[CH2:26][CH2:25]1>>[F:1][C:2]([F:13])([F:12])[CH2:3][O:4][CH2:5][CH2:6][N:14]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:16]=[C:15]1[NH:23][CH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 30184551-Piperidinecarboxylic acid, 4-(1H-benzimidazol-2-ylamino)-, ethyl esterHCID 186737182-Methanesulfonyloxyethyl 2,2,2-trifluorethyl ether

Product 1

HCID 22009486(1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine

Procedure

Prepare by the method of Preparation 14 using 2-methanesulfonyloxyethyl 2,2,2-trifluoroethyl ether and (1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine to give the title compound.

Sources & evidence

ORD record
ord-5831e1c1fd1f43e6be799f6d335bff53
Source dataset
uspto-grants-1999_07
Patent number
US05922737

Reaction notes

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