Hydrazine hydrate (1:1) → 3-(7-Methoxy-3,4-dihydronaphthalen-1-yl)propylamine

HRID 582198Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 582198
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]=[C:10]2[CH2:13][CH2:14][CH2:15][N:16]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:5][CH:4]=1.O.NN>C(O)C>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]=[C:10]2[CH2:13][CH2:14][CH2:15][NH2:16])=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 219964552-[3-(7-Methoxy-3,4-dihydronaphthalen-1-yl)propyl]isoindole-1,3-dione

Produkt 1

HCID 219964393-(7-Methoxy-3,4-dihydronaphthalen-1-yl)propylamineAusbeute 77,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-[3-(7-methoxy-3,4-dihydronaphthalen-1-yl)propyl]isoindole-1,3-dione (11.8 g, 34.0 mmol.) and hydrazine monohydrate (5.1 g, 0.1 mol.) was heated in ethanol (150 ml) for one hour under reflux. The reaction mixture was ice-cooled, then resulting insolubles were filtered off. The filtrate was concentrated under reduced pressure to afford the titled compound (5.7 g, yield 77%, oily). This compound was used for the subsequent reaction without further purification.

Aufarbeitung

  1. temperatureunder reflux
  2. temperaturecooled
  3. filtrationresulting insolubles were filtered off
  4. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7f793a16570f49409b5254c490d9fa43
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05922771

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