Ethanol hydrochloride → HCID 70189071, compound

HRID 582204Notes

Reaction equation

HRID 582204 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])/[C:7](=[CH:13]/[CH2:14][NH2:15])/[CH2:6][CH2:5]2.[ClH:16].C(O)C>>[ClH:16].[Br:1][C:2]1[CH:3]=[C:4]2[C:8]([C:7]([CH2:13][CH2:14][NH2:15])=[CH:6][CH2:5]2)=[CH:9][C:10]=1[O:11][CH3:12]

Participants

3

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 70189085HCID 70189085, compound

Product 1

HCID 70189071HCID 70189071, compoundYield 81%

Procedure

(E)-2-(5-Bromo-6-methoxyindan-1-ylidene)ethylamine (5.0 g, 18.6 mmol) was dissolved in saturated HCl/ethanol (200 ml) and the solution was refluxed for 2 hours. After cooling, the solvent was distilled off under reduced pressure and the resulting crystals were washed with diethyl ether to provide the title compound (yield 4.61 g, 81%).

Workup

  1. temperaturethe solution was refluxed for 2 hours
  2. temperatureAfter cooling
  3. distillationthe solvent was distilled off under reduced pressure
  4. washthe resulting crystals were washed with diethyl ether

Sources & evidence

ORD record
ord-fb9c0479f8634848ab81cac23ff26593
Source dataset
uspto-grants-1999_07
Patent number
US05922771

Reaction notes

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