Acetic Anhydride → HCID 54485229, compound

HRID 582256Notes

Reaction equation

HRID 582256 reaction equation
[C:1]1([CH:11]([CH2:16][C:17](O)=[O:18])[CH2:12][C:13]([OH:15])=[O:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C(OC(=O)C)(=O)C>C(OC(C)C)(C)C>[C:1]1([CH:11]2[CH2:16][C:17](=[O:18])[O:14][C:13](=[O:15])[CH2:12]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 54033015HCID 54033015, compound

Product 1

HCID 54485229HCID 54485229, compound

Reagents, catalysts & solvents 1

HCID 7914Diisopropyl EtherSolvent

Procedure

20 g of 3-(1-naphthyl) glutaric acid (0.0774 moles) prepared by the method described by Hey et al [J. Chem. Soc. 1949, 3177-81] were suspended in 400 mL of isopropyl ether. 36.5 mL of acetic anhydride (0.387 moles) were added and the suspension, well agitated, was heated under reflux for three hours. At the end of this time, the mixture was cooled to ambient temperature and the precipitate filtered off and washed well with isopropyl ether. After drying at 60° C. under vacuum, 13.9 g of the product were recovered.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for three hours
  3. filtrationthe precipitate filtered off
  4. washwashed well with isopropyl ether
  5. dry with materialAfter drying at 60° C. under vacuum, 13.9 g of the product
  6. customwere recovered

Sources & evidence

ORD record
ord-def01612f989465c8254ebaaefca7e39
Source dataset
uspto-grants-1999_07
Patent number
US05922875

Reaction notes

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