反应详情

温度

25 °C

A solution of 20.1 g (140 mmol) of 6-chloro-2-pyridylhydrazine (synthesis: Chem. Ber. 103. (1970) 1960) are added dropwise at 15°-20° C. to a mixture of 12.4 g (182 mmol) of sodium ethoxide, 100 ml of ethanol and 100 ml of toluene. After stirring for 2 hours at 25° C., the reaction mixture is evaporated, the residue is taken up in water and extracted with MTBE. The aqueous phase is adjusted to a pH of 6.5 and cooled to 5° C. The precipitate formed is filtered off and dried under reduced pressure at 40° C.

1. customthe reaction mixture is evaporated
2. extractionextracted with MTBE
3. temperaturecooled to 5° C
4. customThe precipitate formed
5. filtrationis filtered off
6. customdried under reduced pressure at 40° C.