(S)-(+)-1-Aminopropan-2-ol → HCID 86754239, compound

HRID 582316Notes

Reaction equation

HRID 582316 reaction equation
CO[C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([NH:24][CH:25]([CH3:27])[CH3:26])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[CH:6][CH:5]=1.[NH2:29][CH2:30][C@@H:31]([OH:33])[CH3:32]>>[OH:33][C@@H:31]([CH3:32])[CH2:30][NH:29][C:3]([C:4]1[CH:5]=[CH:6][C:7]([C:10]([N:12]2[CH2:13][CH2:14][N:15]([C:18]3[C:23]([NH:24][CH:25]([CH3:26])[CH3:27])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:16][CH2:17]2)=[O:11])=[CH:8][CH:9]=1)=[O:28]

Participants

3

Reactant 2

HCID 7311736(S)-(+)-1-Aminopropan-2-olHCID 53711670HCID 53711670, compound

Product 1

HCID 86754239HCID 86754239, compoundYield 81%

Procedure

By the same procedure as described in the example 31, synthesis was carried out starting with 4-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid methyl ester and using (S)-(+)-1-amino-2-propanol. Then, the product was recrystallized using isopropanol and tetrahydrofuran to give the desired compound.

Workup

  1. customBy the same procedure as described in the example 31, synthesis
  2. customThen, the product was recrystallized

Sources & evidence

ORD record
ord-d7eeef956b204721a137a836e61d7e13
Source dataset
uspto-grants-1999_07
Patent number
US05922871

Reaction notes

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