N-(2-Aminoethyl)piperidine → HCID 54443688, compound

HRID 582321Notes

Reaction equation

HRID 582321 reaction equation
CO[C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([NH:24][CH:25]([CH3:27])[CH3:26])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[CH:6][CH:5]=1.[NH2:29][CH2:30][CH2:31][N:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH:25]([NH:24][C:23]1[C:18]([N:15]2[CH2:16][CH2:17][N:12]([C:10]([C:7]3[CH:6]=[CH:5][C:4]([C:3](=[O:28])[NH:29][CH2:30][CH2:31][N:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)=[CH:9][CH:8]=3)=[O:11])[CH2:13][CH2:14]2)=[N:19][CH:20]=[CH:21][CH:22]=1)([CH3:26])[CH3:27]

Participants

3

Reactant 2

HCID 33944N-(2-Aminoethyl)piperidineHCID 537116704-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid methyl ester

Product 1

HCID 54443688HCID 54443688, compoundYield 70%

Procedure

By the same procedure as described in the example 56, synthesis was carried out starting with 4-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid methyl ester and using 1-(2-aminoethyl)piperidine. Then, the product was recrystallized using acetonitrile and hexane to give the desired compound.

Workup

  1. customBy the same procedure as described in the example 56, synthesis
  2. customThen, the product was recrystallized

Sources & evidence

ORD record
ord-ea0318d6eb174507938270103c76c60f
Source dataset
uspto-grants-1999_07
Patent number
US05922871

Reaction notes

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