N,N-Dimethylethylenediamine → HCID 53648452, compound

HRID 582322Notes

Reaction equation

HRID 582322 reaction equation
CO[C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([NH:24][CH:25]([CH3:27])[CH3:26])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[CH:6][CH:5]=1.[CH3:29][N:30]([CH3:34])[CH2:31][CH2:32][NH2:33]>>[CH3:29][N:30]([CH3:34])[CH2:31][CH2:32][NH:33][C:3]([C:4]1[CH:5]=[CH:6][C:7]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([NH:24][CH:25]([CH3:27])[CH3:26])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[CH:8][CH:9]=1)=[O:28]

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 53711670HCID 53711670, compound

Product 1

HCID 53648452HCID 53648452, compoundYield 79%

Procedure

By the same procedure as described in the example 45, synthesis was carried out starting with 4-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid methyl ester and using N,N-dimethylethylenediamine. Then, the product was recrystallized using ethanol and isopropyl ether to give the desired compound.

Workup

  1. customBy the same procedure as described in the example 45, synthesis
  2. customThen, the product was recrystallized

Sources & evidence

ORD record
ord-ce2586c07fb34aa1bb2a68c45d87ab64
Source dataset
uspto-grants-1999_07
Patent number
US05922871

Reaction notes

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