HCID 54079837, compound → HCID 10926377, compound

HRID 582462Notes

Reaction equation

HRID 582462 reaction equation
C([NH:5][S:6]([C:9]1[CH:14]=[C:13]([CH2:15][N:16]([CH3:21])[S:17]([CH3:20])(=[O:19])=[O:18])[CH:12]=[CH:11][C:10]=1[S:22]([CH3:25])(=[O:24])=[O:23])(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[CH3:21][N:16]([CH2:15][C:13]1[CH:12]=[CH:11][C:10]([S:22]([CH3:25])(=[O:24])=[O:23])=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:14]=1)[S:17]([CH3:20])(=[O:18])=[O:19]

Participants

3

Reactant 1

HCID 54079837HCID 54079837, compound

Product 1

HCID 10926377HCID 10926377, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 1.85 g (4.5 mmol) of N-tert-butyl-5-(N-methyl-N-methanesulfonylaminomethyl)-2-methanesulfonylbenzenesulfonamide in 20 ml of trifluoroacetic acid is stirred at room temperature for 8 h. The mixture is evaporated to dryness and then coevaporated with toluene, and the residue obtained is crystallized from ethyl acetate/diisopropyl ether. 1.32 g (83%) of 5-(N-methyl-N-methanesulfonylaminomethyl)-2-methanesulfonylbenzenesulfonamide of melting point 165-169° C. are obtained.

Workup

  1. customThe mixture is evaporated to dryness
  2. customthe residue obtained
  3. customis crystallized from ethyl acetate/diisopropyl ether

Sources & evidence

ORD record
ord-a1696c0652414cfb953a6741efb6b1b7
Source dataset
uspto-grants-1999_07
Patent number
US05925596

Reaction notes

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