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HRID582540

反应详情

EQUATION

反应方程式

HRID 582540 的结构方程式

REACTANTS

反应物

2
结构：Clc1ncc2[nH]cnc2n1
HCID519314

2-chloro-9H-purine

C5H3ClN4

结构：CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(N[C@@H]4CCC[C@H]4O)nc32)[C@H](O)[C@@H]1O
HCID44352986

未命名化合物

PRODUCTS

生成物

1
结构：CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NC4CCCC4)nc32)[C@H](O)[C@@H]1O
HCID44352987

未命名化合物

PROCEDURE

实验过程

(1R-trans)-1-deoxy-1-[6-[(2,2-diphenylethyl)amino]-2-[(2-hydroxycyclopentyl)amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide, from the 2-chloropurine (0.35 g) and (R)-(trans)-2-aminocyclopentanol1 (1.0 g) at 130° C. for 10h. The product was purified on silica eluting with ethyl acetate:methanol 19:1 and then on silica eluting with dichloromethane:methanol:0.880 ammonia (100:8:1). The product had m.p. 122 to 130° C. Analysis found C,62.6, H,6.2, N,16.2%; C31H37N7O5.0.4H2O requires C,62.6, H,6.4, N,16.5%.

WORKUP

后处理

  1. customThe product was purified on silica eluting with ethyl acetate:methanol 19:1