2-chloro-7H-purine → (2-(Cyclopentylamino)-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl]-1-deoxy-N-ethyl-beta-D-ribofuranuronamide

Participants

Reaction Steps

(1R-trans)-1-deoxy-1-[6-[(2,2-diphenylethyl)amino]-2-[(2-hydroxycyclopentyl)amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide, from the 2-chloropurine (0.35 g) and (R)-(trans)-2-aminocyclopentanol1 (1.0 g) at 130° C. for 10h. The product was purified on silica eluting with ethyl acetate:methanol 19:1 and then on silica eluting with dichloromethane:methanol:0.880 ammonia (100:8:1). The product had m.p. 122 to 130° C. Analysis found C,62.6, H,6.2, N,16.2%; C31H37N7O5.0.4H2O requires C,62.6, H,6.4, N,16.5%.

Provenance & Evidence