Trifluoroacetic acid → HCID 18630707, compound

HRID 582573Notes

Reaction equation

HRID 582573 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:18]([CH:19]=[CH2:20])[CH2:17][N:16]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27](=[NH:29])[NH2:28])[CH:22]=3)[C:15]2=[O:30])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:18]([CH:19]=[CH2:20])[CH2:17][N:16]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27](=[NH:28])[NH2:29])[CH:22]=3)[C:15]2=[O:30])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18630661HCID 18630661, compound

Product 1

HCID 18630707HCID 18630707, compoundYield 130.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(1-t-Butoxycarbonylpiperidin-4-yl)-3-(3-amidinophenyl)-5-ethenyl-2-imidazolidinone (1.32 g, 3.3 mmol) was stirred in 1:1 dichloromethane:trifluoroacetic acid (30 ml) for 4 h. This solvent was removed in vacuo, and 1.35 g of 1-(piperidin-4-yl)-3-(3-amidinophenyl)-5-ethenyl-2-imidazolidinone was obtained as the trifluoroacetic acid salt LRMS (M+H)+ m/z 297.

Workup

  1. customThis solvent was removed in vacuo

Sources & evidence

ORD record
ord-3d9c15447e0f4870bdc6d1c0f6186b7d
Source dataset
uspto-grants-1999_07
Patent number
US05925635

Reaction notes

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