HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 57301438, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Bromoacetic Acid | HCID 6227 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(4-Cyanobenzyl)-5-hydroxymethyl-1H-imidazole | HCID 10198247 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57301438 | HCID 57301438 | — |
Reaction Steps
A solution of 2-bromoacetic acid in THF at room temperature is treated with excess sodium hydride for 15 minutes. To this mixture is added 1-(4-cyanobenzyl)-5-(hydroxymethyl)imidazole (Example 1) and the mixture is then heated. Upon cooling, the mixture is poured into H2O and EtOAc, extracted with EtOAc (3×), washed with brine, dried (MgSO4), filtered and evaporated to give the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05925651 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-900af917119e40ff9fa8682be508a310 |
| Source note | uspto-grants-1999_07 |