反应详情

温度

0 °C

Thionyl chloride (2 ml) was added dropwise to a stirred, ice cooled solution of 2-[N-benzyl-N-methylamino]ethanol (4 g) obtained in preparation 8, in dry benzene (10 ml). The resulting mixture was stirred at 0° C. for 2 h and then diluted with ethyl acetate (40 ml), washed with saturated aqueous sodium bicarbonate solution (2×25 ml), water (50 ml), brine (50 ml) and dried. The ethyl acetate layer was evaporated and the residue was chromatographed on silica gel with 20% ethyl acetate in petroleum ether as eluent to give 2.6 g of the title compound.

1. washwashed with saturated aqueous sodium bicarbonate solution (2×25 ml), water (50 ml), brine (50 ml)
2. customdried
3. customThe ethyl acetate layer was evaporated
4. customthe residue was chromatographed on silica gel with 20% ethyl acetate in petroleum ether as eluent