Sodium Hydroxide → HCID 86754261, compound

HRID 582688Notes

Reaction equation

HRID 582688 reaction equation
C[O:2][C:3](=[O:39])[C@@H:4]([NH:28][C:29]([O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])[CH2:5][NH:6][C:7]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[CH2:14][N:13](CCNC1C=CC=CN=1)[C:12]2=O)=[O:8].[OH-:40].[Na+]>CO>[CH2:14]1[C:15]2[C:11](=[CH:10][C:9]([C:7]([NH:6][CH2:5][C@H:4]([NH:28][C:29]([O:31][C:32](=[O:40])[C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[O:30])[C:3]([OH:2])=[O:39])=[O:8])=[CH:17][CH:16]=2)[CH2:12][NH:13]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86754262HCID 86754262, compound

Product 1

HCID 86754261HCID 86754261, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A methanol solution (25 mL) of 5-2 (328 mg, 0.61 mmol) and 1N NaOH (5 mL, 5 mmol) was stirred under ambient conditions overnight. The reaction was concentrated to dryness and the residue dissolved in H2O and the solution acidified with 6 N HCl to provide 5-3 as a solid.

Workup

  1. concentrationThe reaction was concentrated to dryness
  2. dissolutionthe residue dissolved in H2O

Sources & evidence

ORD record
ord-80a2df4b87f04e5e985a46a5d5cf2da5
Source dataset
uspto-grants-1999_07
Patent number
US05925655

Reaction notes

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