Sodium Hydroxide → 3-Oxo-2-[2-(pyrimidin-2-ylamino)ethyl]-2,3-dihydro-1H-isoindole-5-carboylic acid

Participants

Reaction Steps

A methanol solution (25 mL) of ester 6-3 (400 mg, 1.28 mmol) and 1 N NaOH (5 mL, 5 mmol) was stirred under ambient conditions for 18 hr. The reaction solution was concentrated to dryness and the residue was neutralized with 1 M NaHSO4 solution to provide 6-4 as a pale yellow solid.

Provenance & Evidence