Sodium Hydroxide → HCID 86754268, compound

HRID 582695Notes

Reaction equation

HRID 582695 reaction equation
C[O:2][C:3](=[O:38])[C@@H:4]([NH:28][S:29]([C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1)(=[O:31])=[O:30])[CH2:5][NH:6][C:7]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[CH2:14][N:13](CCNC1C=CC=CN=1)[C:12]2=O)=[O:8].[OH-].[Na+]>CO>[CH2:14]1[C:15]2[C:11](=[CH:10][C:9]([C:7]([NH:6][CH2:5][C@H:4]([NH:28][S:29]([C:32]3[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=3)(=[O:30])=[O:31])[C:3]([OH:38])=[O:2])=[O:8])=[CH:17][CH:16]=2)[CH2:12][NH:13]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86754269HCID 86754269, compound

Product 1

HCID 86754268HCID 86754268, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A methanol solution (3 mL) of 8-2 (184 mg, 0.34 mmol) and 1 N NaOH (3.4 mL, 3.4 mmol) was stirred under ambient conditions for 3 h. The reaction was concentrated to dryness and the residue dissolved in H2O and neutralized with 1 N HCl to provide 8-3 as a solid.

Workup

  1. concentrationThe reaction was concentrated to dryness
  2. dissolutionthe residue dissolved in H2O and neutralized with 1 N HCl

Sources & evidence

ORD record
ord-80b424498a9b4a6da4837360cdbe9208
Source dataset
uspto-grants-1999_07
Patent number
US05925655

Reaction notes

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