反应详情

温度

110 °C

A mixture of 7-(1-aminoethyl)-6-(3,5-difluorophenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one (0.040 g, 0.13 mmol), 2-amino-6-bromopurine (0.056 g, 0.26 mmol), and N,N-diisopropylethylamine (0.045 mL, 0.26 mmol) in ethanol (0.5 mL) was heated at 110° C. overnight. The mixture was filtered, and the filtrate was purified on preparative-LCMS (XBridge C18 Column, eluting with a gradient of acetonitrile/water containing 0.15% NH4OH), to give the desired product. LCMS calculated for C19H15F2N8OS (M+H)+: m/z=441.1. Found: 441.1.

1. filtrationThe mixture was filtered
2. customthe filtrate was purified on preparative-LCMS (XBridge C18 Column
3. washeluting with a gradient of acetonitrile/water containing 0.15% NH4OH),