Toluene → 3-Methyl-N-phenylbutanimidic acid

HRID 582756Notes

Reaction equation

HRID 582756 reaction equation
C([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])(C)C.C(O[C:15](=[O:17])[CH3:16])(=O)C.[C:18]1(C)[CH:23]=CC=C[CH:19]=1>>[CH:18]([CH2:16][C:15]([NH:6][C:5]1[CH:4]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:17])([CH3:23])[CH3:19]

Participants

4

Reactant 3

HCID 1140TolueneHCID 7918Acetic AnhydrideHCID 125612-Isopropylaniline

Product 1

HCID 2229413-Methyl-N-phenylbutanimidic acid

Procedure

A mixture containing 300 ml of toluene and 31 ml of 2-isopropylaniline is cooled in ice, and 22 ml of acetic anhydride are added slowly. After 40 minutes with stirring at RT, the reaction medium is evaporated and the residue is then taken up with petroleum ether. The precipitate formed is drained. 35.9 g of the expected product are obtained after crystallization in petroleum ether, m.p.=81° C.

Workup

  1. temperatureis cooled in ice
  2. customthe reaction medium is evaporated
  3. customThe precipitate formed

Sources & evidence

ORD record
ord-bd9c4bb791a64485a23ba2fe76eab398
Source dataset
uspto-grants-1999_07
Patent number
US05925661

Reaction notes

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