Hydrochloric Acid → HCID 22111899, compound

HRID 582767Notes

Reaction equation

HRID 582767 reaction equation
C([NH:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][C:6]=1[CH:13]1[CH2:15][CH2:14]1)(=O)C.[ClH:16]>C(O)C.O>[ClH:16].[NH2:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][C:6]=1[CH:13]1[CH2:14][CH2:15]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22111788N-(4-Cyano-2-cyclopropylphenyl)acetamide

Product 1

HCID 22111899HCID 22111899, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 2.39 g of the product of step A dissolved in 45 ml of ethanol with 36 ml of water and 5 ml of concentrated HCl is stirred for 12 hours under reflux. The ethanol is evaporated off under vacuum, and the precipitate is filtered off, washed with 1 ml of water and dried under vacuum to obtain 1.5 g of the expected product.

Workup

  1. temperatureunder reflux
  2. customThe ethanol is evaporated off under vacuum
  3. filtrationthe precipitate is filtered off
  4. washwashed with 1 ml of water
  5. customdried under vacuum

Sources & evidence

ORD record
ord-47d6de9a4954419b9b675ace2dd74766
Source dataset
uspto-grants-1999_07
Patent number
US05925661

Reaction notes

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