Acetic Anhydride → 1-Acetamido-5,6,7,8-tetrahydronaphthalene

HRID 582775Notes

Reaction equation

HRID 582775 reaction equation
[NH2:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(Cl)Cl>[C:12]([NH:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1)(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 166715-Tetralinylamine

Product 1

HCID 2320651-Acetamido-5,6,7,8-tetrahydronaphthalene

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 24.39 g of 1-amino-5,6,7,8-tetrahydronaphthalene and 18.6 ml of acetic anhydride in 230 ml of DCM is left stirring for 1 hour at RT. It is concentrated under vacuum, the residue is taken up with ether and the precipitate formed is drained. 26.8 g of the expected product are obtained, m.p.=158° C.

Workup

  1. waitis left
  2. concentrationIt is concentrated under vacuum
  3. customthe precipitate formed

Sources & evidence

ORD record
ord-b0dbccfe2b204142bafe5aa10bf17715
Source dataset
uspto-grants-1999_07
Patent number
US05925661

Reaction notes

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