反应详情

温度

110 °C

A mixture of 7-(1-aminoethyl)-6-(3-fluorophenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one (0.025 g, 0.086 mmol), 6-bromo-9H-purine (0.031 g, 0.16 mmol), and N,N-diisopropylethylamine (0.027 mL, 0.16 mmol) in ethanol (0.5 mL) was heated at 110° C. overnight. The mixture was filtered and the filtrate was purified on preparative-LCMS (XBridge C18 Column, eluting with a gradient of acetonitrile/water containing 0.15% NH4OH) to give the desired product. LCMS calculated for C19H15FN7OS (M+H)+: m/z=408.1. Found: 408.0.

1. filtrationThe mixture was filtered
2. customthe filtrate was purified on preparative-LCMS (XBridge C18 Column
3. washeluting with a gradient of acetonitrile/water containing 0.15% NH4OH)