Phosphoric Acid → HCID 70246175, compound

HRID 582791Notes

Reaction equation

HRID 582791 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[C:11]1[N:15]([C:16]2[CH:21]=[CH:20][C:19]([C:22](=[O:31])[N:23]([CH3:30])[CH2:24][CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])=[CH:18][C:17]=2[CH:32]([CH3:34])[CH3:33])[N:14]=[C:13]([C:35]([NH:37][C:38]2([C:48]([OH:50])=[O:49])[CH:45]3[CH2:46][CH:41]4[CH2:42][CH:43]([CH2:47][CH:39]2[CH2:40]4)[CH2:44]3)=[O:36])[CH:12]=1.[P:51](=[O:55])([OH:54])([OH:53])[OH:52]>C(Cl)Cl.CCO>[P:51]([OH:55])([OH:54])([OH:53])=[O:52].[CH3:10][O:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[C:4]=1[C:11]1[N:15]([C:16]2[CH:21]=[CH:20][C:19]([C:22](=[O:31])[N:23]([CH3:30])[CH2:24][CH2:25][CH2:26][N:27]([CH3:28])[CH3:29])=[CH:18][C:17]=2[CH:32]([CH3:34])[CH3:33])[N:14]=[C:13]([C:35]([NH:37][C:38]2([C:48]([OH:50])=[O:49])[CH:39]3[CH2:40][CH:41]4[CH2:42][CH:43]([CH2:44][CH:45]2[CH2:46]4)[CH2:47]3)=[O:36])[CH:12]=1

Participants

5

Reactant 2

HCID 1004Phosphoric AcidHCID 5311451SR142948A

Product 1

HCID 70246175HCID 70246175, compoundYield 35%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 0.1 g of the compound obtained in EXAMPLE 1' and 0.017 g of 85% orthophosphoric acid in 2 ml of DCM and 3 ml of EtOH is left stirring for 1 hour at. RT. It is partially concentrated under vacuum and poured into 10 ml of ether cooled to 50° C., and the precipitate formed is drained. 0.04 g of the expected product is obtained after drying at 60° C.

Workup

  1. waitis left
  2. customRT
  3. concentrationIt is partially concentrated under vacuum
  4. additionpoured into 10 ml of ether
  5. customthe precipitate formed

Sources & evidence

ORD record
ord-feb957ddf2a34cb88d6f54fd3d636d67
Source dataset
uspto-grants-1999_07
Patent number
US05925661

Reaction notes

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