反应详情

6-Methoxymethoxy-N-[2-(4-thiomorpholinyl)ethyl]-1,2-benzisoxazol-3-amine (1.6 g Example 22) was dissolved in methanolic hydrochloric acid (40 ml) and stirred under nitrogen for 24 hours. The reaction was neutralized with saturated Na2CO3 solution, and extracted with EtOAc. The organic phase was dried over MgSO4 and concentrated in vacuo. The resulting residue was filtered through a silica gel filter-cake eluting with 5% MeOH/DCM, concentrated in vacuo, and subsequent titration with EtOAc provided the product (1.0 g).

1. extractionextracted with EtOAc
2. dry with materialThe organic phase was dried over MgSO4
3. concentrationconcentrated in vacuo
4. filtrationThe resulting residue was filtered through a silica gel
5. filtrationfilter-cake
6. washeluting with 5% MeOH/DCM
7. concentrationconcentrated in vacuo, and subsequent titration with EtOAc