反应详情

温度

130 °C

16 g of propionyl chloride are added dropwise to a mixture of 18 ml of o-chlorotoluene and 22.7 g of aluminum chloride and the reaction mixture is then heated at 130° C. for 3 hours. After cooling to RT, it is poured into a mixture of 100 ml of concentrated HCl and ice, extracted with ether, the organic phase is washed with saturated NaHCO3 solution and dried over Na2SO4 and the solvent is evaporated off under vacuum. The residue is distilled off under reduced pressure to give 20.7 g of the expected product which crystallizes. B.p.=95° C. under 5 Pa.

1. temperatureAfter cooling to RT
2. extractionextracted with ether
3. washthe organic phase is washed with saturated NaHCO3 solution
4. dry with materialdried over Na2SO4
5. customthe solvent is evaporated off under vacuum
6. distillationThe residue is distilled off under reduced pressure