HCID 21225311, compound → HCID 21225413, compound

HRID 582986Notes

Reaction equation

HRID 582986 reaction equation
[F:1][C:2]([F:16])([C:9]([F:15])([F:14])[C:10]([F:13])([F:12])[F:11])[CH2:3][O:4][CH2:5][CH2:6][CH2:7]Cl.[CH2:17]([O:27][C:28]1[CH:29]=[N:30][C:31]([C:34]2[CH:39]=[CH:38][C:37]([OH:40])=[CH:36][CH:35]=2)=[N:32][CH:33]=1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>>[CH2:17]([O:27][C:28]1[CH:29]=[N:30][C:31]([C:34]2[CH:35]=[CH:36][C:37]([O:40][CH2:7][CH2:6][CH2:5][O:4][CH2:3][C:2]([F:16])([F:1])[C:9]([F:15])([F:14])[C:10]([F:13])([F:12])[F:11])=[CH:38][CH:39]=2)=[N:32][CH:33]=1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

Participants

3

Reactant 2

HCID 21225311HCID 21225311, compoundHCID 135585896110203-06-0

Product 1

HCID 21225413HCID 21225413, compound

Procedure

The title compound was prepared essentially as in Example 1 by combining 3-(2,2,3,3,4,4,4-heptafluorobutoxy)propyl chloride (4.1 g of 68% purity, 10.7 mmol, prepared from 1,3-dichloropropane and 2,2,3,3,4,4,4-heptafluorobutanol) with 5-decyloxy-2-(4-hydroxyphenyl)pyrimidine (3.5 g, 10.7 mmol). The resulting crude product was isolated essentially as described in Example 3 and purified by chromatography on silica gel, eluting with 10 vol. % ethyl acetate in hexane, followed by Kugelrohr distillation (220° C. at 0.5 torr) to provide a yield of 4.8 g.

Sources & evidence

ORD record
ord-668ee93b95f547d5b3833848ca110efb
Source dataset
uspto-grants-1999_07
Patent number
US05928562

Reaction notes

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