1-Iodooctane → HCID 21225281, compound
Reaction equation
[OH:1][C:2]1[CH:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][C:20]([O:23][C:24]([F:43])([F:42])[C:25]([F:41])([F:40])[O:26][C:27]([F:39])([F:38])[C:28]([F:37])([F:36])[C:29]([F:35])([F:34])[C:30]([F:33])([F:32])[F:31])([F:22])[F:21])=[C:10]([F:44])[C:9]=2[F:45])=[N:6][CH:7]=1.I[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH3:54]>>[CH2:47]([O:1][C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][C:20]([O:23][C:24]([F:43])([F:42])[C:25]([F:40])([F:41])[O:26][C:27]([F:38])([F:39])[C:28]([F:36])([F:37])[C:29]([F:34])([F:35])[C:30]([F:31])([F:32])[F:33])([F:21])[F:22])=[C:10]([F:44])[C:9]=2[F:45])=[N:4][CH:3]=1)[CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH3:54]Participants
3
Procedure
The title compound was prepared essentially as in Example 12 by combining 5-hydroxy-2-[4-(3-(2-(2-(nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propoxy)-2,3-difluorophenyl)pyrimidine (1.0 g, 1.4 mmol, prepared essentially as described in DE 4,220,065) with iodooctane (0.31 g, 1.5 mmol). The resulting crude product was isolated essentially as described in Example 3 and purified by chromatography on silica gel, eluting with toluene, followed by Kugelrohr distillation (200° C. at 0.15 torr) to provide a yield of 0.3 g.
Workup
- customprepared essentially
Sources & evidence
- ORD record
- ord-61f8931375784f898e4c2478d258bdf9
- Source dataset
- uspto-grants-1999_07
- Patent number
- US05928562
Reaction notes
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