1-Iodooctane → HCID 21225281, compound

Participants

Reaction Steps

The title compound was prepared essentially as in Example 12 by combining 5-hydroxy-2-[4-(3-(2-(2-(nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propoxy)-2,3-difluorophenyl)pyrimidine (1.0 g, 1.4 mmol, prepared essentially as described in DE 4,220,065) with iodooctane (0.31 g, 1.5 mmol). The resulting crude product was isolated essentially as described in Example 3 and purified by chromatography on silica gel, eluting with toluene, followed by Kugelrohr distillation (200° C. at 0.15 torr) to provide a yield of 0.3 g.

Provenance & Evidence