Water → HCID 21226441, compound

HRID 583041Notes

Reaction equation

HRID 583041 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]([C:10]2[C:14]([Cl:15])=[C:13]([O:16][CH:17]([F:19])[F:18])[N:12]([CH3:20])[N:11]=2)[CH:6]=[CH:7][C:8]=1[Cl:9].[C:21]([O-:24])(=[O:23])[CH3:22].[Na+].O>CN(C)C=O>[C:21]([O:24][CH2:2][C:3]1[CH:4]=[C:5]([C:10]2[C:14]([Cl:15])=[C:13]([O:16][CH:17]([F:19])[F:18])[N:12]([CH3:20])[N:11]=2)[CH:6]=[CH:7][C:8]=1[Cl:9])(=[O:23])[CH3:22]

Participants

5

Reactant 3

HCID 962WaterHCID 517045Sodium AcetateHCID 15220187HCID 15220187, compound

Product 1

HCID 21226441HCID 21226441, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 6.8 g (18 mmol) of 3-(3-bromomethyl-4-chlorophenyl)-4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazole and 1.5 g (18 mmol) of sodium acetate in 20 ml of dimethylformamide was stirred overnight and then stirred into 100 ml of cold water. The product was extracted from the aqueous phase using ethyl acetate. The ethyl acetate phase was dried over magneisum sulfate and concentrated. The crude product thus obtained was purified by silica gel chromatography (eluent: hexane/ethyl acetate=9:1). Yield: 4.7 g.

Workup

  1. extractionThe product was extracted from the aqueous phase
  2. dry with materialThe ethyl acetate phase was dried over magneisum sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-eaf2b77f50074646850fe9f17081f419
Source dataset
uspto-grants-1999_07
Patent number
US05928999

Reaction notes

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