反应详情

A suspension of N-(1-methylethyl)-(2-nitro-6-fluorophenyl)methylamine (0.4 g, 1.89 mmol), tin chloride dihydrate (1.75 g) in water (8 ml) was added HCl 12N (2 ml). The mixture was refluxed for 4 hours. Then, the reaction mixture was allowed to reach room temperature and was neutralized by addition of NaOH 2N and extracted with diethyl ether (1×100 ml), dried over MgSO4 and evaporated under reduced pressure to afford N-(1-methylethyl)-(2-amino-6-fluorophenyl)methylamine.

1. temperatureThe mixture was refluxed for 4 hours
2. customto reach room temperature
3. extractionextracted with diethyl ether (1×100 ml)
4. dry with materialdried over MgSO4
5. customevaporated under reduced pressure