反应详情

A mixture comprising 0.3 g of 4-chloro-5-[3-(4-methylpiperazin-1-yl)-carbonylmethoxy-4-methoxybenzylamino]-3(2H)-pyridazinone, 2.0 g of potassium hydroxide, 10 ml of ethanol and 2 ml of water, was refluxed under heating with stirring overnight. The reaction solution was neutralized with an aqueous hydrochloric acid solution. Then, the solvent was distilled off under reduced pressure. Then, water was added to the obtained residue, and the mixture was extracted with chloroform. The extract solution was washed with water and a saturated sodium chloride aqueous solution and then dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain 212 mg of the above-identified compound as white solid.

1. temperaturewas refluxed
2. temperatureunder heating
3. distillationThen, the solvent was distilled off under reduced pressure
4. additionThen, water was added to the obtained residue
5. extractionthe mixture was extracted with chloroform
6. washThe extract solution was washed with water
7. dry with materiala saturated sodium chloride aqueous solution and then dried over anhydrous sodium sulfate
8. distillationThen, the solvent was distilled off