Chloroform → HCID 21584181, compound

HRID 583119Notes

Reaction equation

HRID 583119 reaction equation
[Br:1][C:2]1[C:3](=[O:35])[NH:4][N:5]=[CH:6][C:7]=1[NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][N:24]([CH2:27][C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=3)[CH2:23][CH2:22]2)[CH:11]=1.[C:36]([OH:43])(=[O:42])/[CH:37]=[CH:38]/[C:39]([OH:41])=[O:40].C(Cl)(Cl)Cl>C(OCC)C>[C:36]([OH:43])(=[O:42])/[CH:37]=[CH:38]/[C:39]([OH:41])=[O:40].[Br:1][C:2]1[C:3](=[O:35])[NH:4][N:5]=[CH:6][C:7]=1[NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][N:24]([CH2:27][C:28]3[CH:29]=[CH:30][C:31]([Cl:34])=[CH:32][CH:33]=3)[CH2:23][CH2:22]2)[CH:11]=1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 444972Fumaric AcidHCID 4913106HCID 4913106, compound

Product 1

HCID 21584181HCID 21584181, compoundYield 62.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture comprising 163 mg of 4-bromo-5-[3-{2-(4-(4-chlorobenzyl)-piperazin-1-yl)-ethoxy}-4-methoxybenzylamino]-3(2H)-pyridazinone, 33 mg of fumaric acid and 4 ml of chloroform, was stirred at room temperature for 3 hours. Diethyl ether was added to the reaction solution for crystallization to obtain 120 mg of the above-identified compound as white crystals having a melting point of from 178-185° C.

Sources & evidence

ORD record
ord-b20965b3f5eb4e1c998156b21558db66
Source dataset
uspto-grants-1999_07
Patent number
US05929074

Reaction notes

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