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HRID58312

反应详情

EQUATION

反应方程式

HRID 58312 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C
HCID11120686

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)CC[C@@H](C(=O)OC(C)(C)C)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
HCID11165987

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

2 次

PROCEDURE

实验过程

13.4 g of Boc-Glu(OMe)-OtBu (˜39.6 mmol) are dissolved in 30 mL of acetonitrile and treated with 986 mg of DMAP (7.91 mmol, 0.2 eq). Under nitrogen atmosphere a solution of 17.6 g of di-tert-butylbicarbonate (77.1 mmol, 2 eq) in 100 mL of acetonitrile is added. After stirring overnight, the solvent is removed in vacuo and the obtained crude product is purified by chromatography on silica gel (column: 31*6.0 cm, petroleum ether/ethyl acetate 9:1)

WORKUP

后处理

  1. customthe solvent is removed in vacuo
  2. customthe obtained crude product
  3. customis purified by chromatography on silica gel (column: 31*6.0 cm, petroleum ether/ethyl acetate 9:1)