2-Bromopropane → HCID 67565563, compound

HRID 583132Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:13]2[O:17][C:16](=[O:18])[N:15]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[N:14]=2)[C:6]2[O:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:12]=1.Br[CH:26]([CH3:28])[CH3:27]>>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([C:13]2[O:17][C:16](=[O:18])[N:15]([CH:19]3[CH2:24][CH2:23][N:22]([CH:26]([CH3:28])[CH3:27])[CH2:21][CH2:20]3)[N:14]=2)[C:6]2[O:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:12]=1

Participants

Reactant 2

HCID 63582-Bromopropane

HCID 21310621HCID 21310621, compound

Product 1

HCID 67565563HCID 67565563, compoundYield 118.9%

Procedure

From 0.5 g (1.34 mmol) of 5-(6-chloro-3,4-dihydro-2H-benzopyran-8-yl)-3- (piperidin-4-yl) -1,3,4-oxadiazol-2(3H)-one hydrochloride and 0.378 g (1.34 mmol) of 1-bromo-1-methylethane, and by carrying out the preparation as described in Example 15, 0.33 g of compound is obtained. Melting point: 241° C.

Workup

customthe preparation

Sources & evidence

ORD record: ord-c2748e02fbae4b7dbe8d02fbce367602
Source dataset: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05929089

Reaction notes

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