Ammonia → 12-Methoxydodecanamide

HRID 583215ノート

反応式

HRID 583215 の反応式
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14](Cl)=[O:15].[NH3:17]>O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([NH2:17])=[O:15]

参加物

4

反応物 2

HCID 222AmmoniaHCID 1961175912-Methoxydodecanoyl chloride

生成物 1

HCID 983750412-Methoxydodecanamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To the title product from Example 11 (1.1 g, 4.3 mmol) in 70 mL of anhydrous tetrahydrofuran was added 20 mL of freshly distilled liquid ammonia in a Parr shaker which was sealed and shaken at room temperature for 16 hours. After filtering and concentration, the crude residue was dissolved in anhydrous methanol and passed through a basic ion exchange resin and eluted with anhydrous methanol. Concentration afforded the title compound (780 mg) as a white solid, m.p. 83.9-85.6° C. (DSC). The structure was supported by NMR, infrared spectroscopy, elemental analysis, and mass spectroscopy.

後処理

  1. customwas sealed
  2. filtrationAfter filtering
  3. concentrationconcentration
  4. dissolutionthe crude residue was dissolved in anhydrous methanol
  5. washeluted with anhydrous methanol
  6. concentrationConcentration

出典と根拠

ORDレコード
ord-fab5aaaf5e9d47d0ad1eb78e7320df21
出典データセット
uspto-grants-1999_07
特許番号
US05929110

反応ノート

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