Hydrochloric Acid → HCID 21584331, compound

HRID 583281Notes

Reaction equation

HRID 583281 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[CH2:8][CH:9]3[CH2:17][NH:16][CH2:15][CH2:14][N:10]3[CH2:11][C:12]=2[CH:13]=1)([O-])=O.[ClH:18].[H][H]>CO.O>[ClH:18].[ClH:18].[ClH:18].[CH2:17]1[CH:9]2[N:10]([CH2:11][C:12]3[CH:13]=[C:4]([NH2:1])[CH:5]=[CH:6][C:7]=3[CH2:8]2)[CH2:14][CH2:15][NH:16]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 21584362HCID 21584362, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 21584331HCID 21584331, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To 8-nitro-2,3,4,6,11,11a-hexahydro-1H-pyrazino[1,2-b]isoquinoline (2.98 g) in methanol (150 ml) and water (10 ml) was added concentrated hydrochloric acid (3.26 ml) and 5% Pd--C (300 mg). The mixture was treated with hydrogen at 50 psi on a Parr Hydrogenator. Hydrogen uptake was complete in 1.0 hour. The catalyst was filtered off and the solvent removed under reduced pressure to yield the title product as a solid (3.69 g).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-0e6f928b3d074f89aa62b4d0abf6bf24
Source dataset
uspto-grants-1999_07
Patent number
US05929085

Reaction notes

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