Methanol → HCID 21310919, compound

HRID 583319Notes

Reaction equation

HRID 583319 reaction equation
CO.C[O:4][C:5](=[O:33])[C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([CH3:13])[C:7]=1[N:14]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[S:15]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)(=[O:17])=[O:16]>CCOCC>[CH2:26]([N:14]([S:15]([C:18]1[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=1)(=[O:17])=[O:16])[C:7]1[C:8]([CH3:13])=[C:9]([Cl:12])[CH:10]=[CH:11][C:6]=1[C:5]([OH:33])=[O:4])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 70053518HCID 70053518, compound

Product 1

HCID 21310919HCID 21310919, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

In the same manner as described in Example 19, except a mixture of MeOH and ThF was used instead of MeOH, 0.506 g (1.1 mmol) of the product of Example 98 provided 0.454 g (93%) of the desired carboxylic acid as a white solid after triion with ether. Electrospray Mass Spec 446.1(M+H).

Sources & evidence

ORD record
ord-be4d8c9546b743cf8265ba87b30725d5
Source dataset
uspto-grants-1999_07
Patent number
US05929097

Reaction notes

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