HRID58332

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(CCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)CN(C)/C(=N/C(=O)OC(C)(C)C)NC(=O)OC(C)(C)C.O=C([O-])C(F)(F)F

HCID178483972

未命名化合物

PRODUCTS

生成物

结构：CN(CC(=O)N(C)CCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C(=N)[NH3+].O=C([O-])C(F)(F)F.O=C([O-])C(F)(F)F

HCID178484699

未命名化合物

收率 18%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

N2—{(E)-[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}-N,N2-dimethyl-N-[3-(triphenylphosphonio)propyl]glycinamide trifluoroacetate (330 mg, 0.43 mmol) was dissolved in trifluoroacetic acid (1.6 ml) and stirred at room temperature for 15 minutes, and the crude was isolated upon removal of volatiles. Purification by preparative HPLC to give the title compound as a white solid following lyophilization (18% yield).

WORKUP

后处理

customthe crude was isolated upon removal of volatiles
customPurification by preparative HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-53df29585d21450a8c370070197b12a9
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09434753B2
来源说明: uspto-grants-2016_09

反应 SMILES

[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].C(OC([NH:15]/[C:16](=[N:46]\C(OC(C)(C)C)=O)/[N:17]([CH3:45])[CH2:18][C:19]([N:21]([CH3:44])[CH2:22][CH2:23][CH2:24][P+:25]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:20])=O)(C)(C)C>FC(F)(F)C(O)=O>[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[NH3+:46][C:16](=[NH:15])[N:17]([CH3:45])[CH2:18][C:19]([N:21]([CH3:44])[CH2:22][CH2:23][CH2:24][P+:25]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)=[O:20]