HCID 178483972, compound → HCID 178484699, compound

HRID 58332Notes

Reaction equation

HRID 58332 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].C(OC([NH:15]/[C:16](=[N:46]\C(OC(C)(C)C)=O)/[N:17]([CH3:45])[CH2:18][C:19]([N:21]([CH3:44])[CH2:22][CH2:23][CH2:24][P+:25]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:20])=O)(C)(C)C>FC(F)(F)C(O)=O>[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[NH3+:46][C:16](=[NH:15])[N:17]([CH3:45])[CH2:18][C:19]([N:21]([CH3:44])[CH2:22][CH2:23][CH2:24][P+:25]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)=[O:20]

Participants

3

Reactant 1

HCID 178483972HCID 178483972, compound

Product 1

HCID 178484699HCID 178484699, compoundYield 18%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

N2—{(E)-[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}-N,N2-dimethyl-N-[3-(triphenylphosphonio)propyl]glycinamide trifluoroacetate (330 mg, 0.43 mmol) was dissolved in trifluoroacetic acid (1.6 ml) and stirred at room temperature for 15 minutes, and the crude was isolated upon removal of volatiles. Purification by preparative HPLC to give the title compound as a white solid following lyophilization (18% yield).

Workup

  1. customthe crude was isolated upon removal of volatiles
  2. customPurification by preparative HPLC

Sources & evidence

ORD record
ord-53df29585d21450a8c370070197b12a9
Source dataset
uspto-grants-2016_09
Patent number
US09434753B2

Reaction notes

Loading…