4-Bromobenzyl bromide → HCID 15859218, compound

HRID 583324Notes

Reaction equation

HRID 583324 reaction equation
[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[C:5]=1[NH:12][S:13]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)(=[O:15])=[O:14].[Br:25][C:26]1[CH:33]=[CH:32][C:29]([CH2:30]Br)=[CH:28][CH:27]=1>CCCCCC.CCOCC>[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[C:5]=1[N:12]([CH2:30][C:29]1[CH:32]=[CH:33][C:26]([Br:25])=[CH:27][CH:28]=1)[S:13]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)(=[O:15])=[O:14]

Participants

4

Reactant 2

HCID 685274-Bromobenzyl bromideHCID 53963569HCID 53963569, compound

Product 1

HCID 15859218HCID 15859218, compoundYield 86.4%

Reagents, catalysts & solvents 1

HCID 21584099Diethylether hexaneSolvent

Procedure

In the same manner as described in Example 9, 0.699 g (2.0 mmol) of the product of Example 62 and 0.6 g (2.4 mmol) of p-bromobenzyl bromide provided 0.896 g (86%) of the desired product as a white solid after trituration with hexane/ether. Electrospray Mass Spec 518.1 (M+H).

Sources & evidence

ORD record
ord-9d91dd06907e45da96d67b8a25b37f92
Source dataset
uspto-grants-1999_07
Patent number
US05929097

Reaction notes

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