HRID58334

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID433294

Lithium chloride

ClLi

结构：CN(CC(=O)NCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)OC(C)(C)C.[Br-]

HCID131737003

未命名化合物

PRODUCTS

生成物

结构：CN(CC(=O)NCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)OC(C)(C)C.[Cl-]

HCID131737005

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID70681

未命名化合物

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of N2-(tert-butoxycarbonyl)-N2-methyl-N-[3-(triphenylphosphonio)propyl]glycinamide bromide (53.7 g, 93.9 mmole) in methylene chloride (450 mL) was stirred with 20 weight percent aqueous lithium chloride containing 2 weight percent tetrabutylammonium chloride (4×150 mL/g). The organic layer was concentrated to dryness give the title compound in quantitative yield.

WORKUP

后处理

concentrationThe organic layer was concentrated to dryness

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3621d7d8476470a9c265f26cb6cbc17
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09434753B2
来源说明: uspto-grants-2016_09

反应 SMILES

[C:1]([O:5][C:6]([N:8]([CH3:35])[CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][P+:16]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br-].[Cl-:37].[Li+]>C(Cl)Cl.[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC>[C:1]([O:5][C:6]([N:8]([CH3:35])[CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][P+:16]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:11])=[O:7])([CH3:3])([CH3:4])[CH3:2].[Cl-:37]