Pyridine → HCID 70055165, compound

HRID 583374Notes

Reaction equation

HRID 583374 reaction equation
[CH3:1][O:2][C:3](=[O:32])[C:4]1[CH:9]=[C:8]([CH2:10]Br)[CH:7]=[C:6]([CH3:12])[C:5]=1[N:13]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[S:14]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1)(=[O:16])=[O:15].[CH2:33]([NH:35][CH2:36][CH3:37])[CH3:34].N1C=CC=CC=1>ClCCl>[CH3:1][O:2][C:3](=[O:32])[C:4]1[CH:9]=[C:8]([CH2:10][N:35]([CH2:36][CH3:37])[CH2:33][CH3:34])[CH:7]=[C:6]([CH3:12])[C:5]=1[N:13]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[S:14]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1)(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 1049PyridineHCID 8021DiethylamineHCID 70053591HCID 70053591, compound

Product 1

HCID 70055165HCID 70055165, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 518.4 mg (1.0 mmole) of the product of Example 279, 0.5 ml (4.8 mmol) of diethylamine and 0.172 ml (2.0 mmol) of pyridine in 10 ml of dichloromethane was stired at room temperature for 18 hr. The resulting mixture washed with water and brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was chromatographed on silica gel with 2% MeOH/CH2Cl2 as eluant to provide 425 mg (83%). Electrospray Mass Spec 511 (M+H).

Workup

  1. washThe resulting mixture washed with water and brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe residue was chromatographed on silica gel with 2% MeOH/CH2Cl2 as eluant
  6. customto provide 425 mg (83%)

Sources & evidence

ORD record
ord-261f42fe32794305a58460d2bace5bae
Source dataset
uspto-grants-1999_07
Patent number
US05929097

Reaction notes

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