反应详情

To a solution of 0.10 g (0.227 mmol) of the product of Example 335 in 5 mL of methanol and 2.0 mL of THF was added 8.6 mg of sodium borohydride. The reaction was stirred for 1 h at room temperature and then concentrated in vacuo. The residue was diluted with dichloromethane, washed with water, and the organics were then dried over Na2SO4, filtered and concentrated in vacuo. The resulting tan solid was washed with ether and dried in vacuo to give 0.086 g (86%) of the alcohol. Electrospray Mass Spec: 442.9 (M+H)+.

1. concentrationconcentrated in vacuo
2. additionThe residue was diluted with dichloromethane
3. washwashed with water
4. dry with materialthe organics were then dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. washThe resulting tan solid was washed with ether
8. customdried in vacuo