Diisopropylethylamine → {4-[(4-{[Amino(imino)methyl](methyl)amino}butanoyl)amino]butyl}(triphenyl)phosphonium bromide

Beteiligte Stoffe

Reaktionsschritte

(4-{[4-(methylamino)butanoyl]amino}butyl)(triphenyl)phosphonium bromide (690 mg, 1.30 mmol) was dissolved in N,N-dimethylformamide (1.4 mL). The resultant solution was treated with 1H-pyrazole-1-carboximidamide hydrochloride (216 mg, 1.47 mmol) and N,N-diisopropylethylamine (0.27 mL, 1.54 mmol). The reaction was stirred overnight at room temperature. More 1H-pyrazole-1-carboximidamide hydrochloride and N,N-diisopropylethylamine can be added to effect further conversion. The reaction mixture in N,N-dimethylformamide was used in the purification without isolation.

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