反应详情

(4-{[4-(methylamino)butanoyl]amino}butyl)(triphenyl)phosphonium bromide (690 mg, 1.30 mmol) was dissolved in N,N-dimethylformamide (1.4 mL). The resultant solution was treated with 1H-pyrazole-1-carboximidamide hydrochloride (216 mg, 1.47 mmol) and N,N-diisopropylethylamine (0.27 mL, 1.54 mmol). The reaction was stirred overnight at room temperature. More 1H-pyrazole-1-carboximidamide hydrochloride and N,N-diisopropylethylamine can be added to effect further conversion. The reaction mixture in N,N-dimethylformamide was used in the purification without isolation.

1. customThe reaction mixture in N,N-dimethylformamide was used in the purification without isolation