HCID 178418257, compound → Dithiobis(2,1-phenylenecarbonyl)bis-L-arginine

HRID 583528Notes

Reaction equation

HRID 583528 reaction equation
CC([O:5][C:6](=[O:50])[C@H:7]([CH2:43][CH2:44][CH2:45][NH:46][C:47](=[NH:49])[NH2:48])[NH:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17][S:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([NH:27][C@H:28]([C:36]([O:38]C(C)(C)C)=[O:37])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:35])[NH2:34])=[O:26])=[O:10])(C)C>ClCCl.FC(F)(F)C(O)=O>[C:11]1([C:9]([NH:8][C@H:7]([C:6]([OH:50])=[O:5])[CH2:43][CH2:44][CH2:45][NH:46][C:47](=[NH:48])[NH2:49])=[O:10])[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17][S:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([NH:27][C@H:28]([C:36]([OH:38])=[O:37])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:34])[NH2:35])=[O:26]

Participants

4

Reactant 1

HCID 178418257HCID 178418257, compound

Product 1

HCID 178418317Dithiobis(2,1-phenylenecarbonyl)bis-L-arginineYield 59.8%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

This compound was prepared according to the general method of Example 122 using N,N'-[Dithiobis (2,1-phenylenecarbonyl)bis-L-arginine-bis(1,1-dimethylethyl) ester, (1.31 g, 2.0 mmol) from Example 127 in 15 mL of dichloromethane and 15 mL of trifluoroacetic acid. The residue was triturated with ethanol and 1N HCl to yield 0.74 g of the title compound, mp 208-211° C.;

Workup

  1. customThis compound was prepared
  2. customThe residue was triturated with ethanol and 1N HCl

Sources & evidence

ORD record
ord-0cb3383803584b089811204e8cfbe602
Source dataset
uspto-grants-1999_07
Patent number
US05929114

Reaction notes

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